diff --git a/packages/isaac-typescript-definitions/src/enums/BackdropType.ts b/packages/isaac-typescript-definitions/src/enums/BackdropType.ts
index 6f165a532..4bc2b48c8 100644
--- a/packages/isaac-typescript-definitions/src/enums/BackdropType.ts
+++ b/packages/isaac-typescript-definitions/src/enums/BackdropType.ts
@@ -67,4 +67,10 @@ export enum BackdropType {
   MINES_SHAFT = 58,
   ASHPIT_SHAFT = 59,
   DARK_CLOSET = 60,
+
+  /** Added in Repentance+. */
+  DEATHMATCH = 61,
+
+  /** Added in Repentance+. */
+  LIL_PORTAL = 62,
 }
diff --git a/packages/isaac-typescript-definitions/src/enums/ButtonAction.ts b/packages/isaac-typescript-definitions/src/enums/ButtonAction.ts
index 6b8185ea9..1e03210c5 100644
--- a/packages/isaac-typescript-definitions/src/enums/ButtonAction.ts
+++ b/packages/isaac-typescript-definitions/src/enums/ButtonAction.ts
@@ -52,14 +52,50 @@ export enum ButtonAction {
   /** This only fires on `InputHook.IS_ACTION_TRIGGERED` (1). */
   MENU_BACK = 15,
 
-  /** This only fires on `InputHook.IS_ACTION_PRESSED` (0). */
-  RESTART = 16,
+  /**
+   * This only fires on `InputHook.IS_ACTION_PRESSED` (0).
+   *
+   * This enum value changed in Repentance+ from 16 to 18.
+   */
+  RESTART_REPENTANCE = 16,
 
-  /** This only fires on `InputHook.IS_ACTION_TRIGGERED` (1). */
-  FULLSCREEN = 17,
+  /**
+   * This only fires on `InputHook.IS_ACTION_TRIGGERED` (1).
+   *
+   * This enum value changed in Repentance+ from 17 to 16.
+   */
+  // eslint-disable-next-line @typescript-eslint/no-duplicate-enum-values
+  FULLSCREEN_REPENTANCE_PLUS = 16,
 
-  /** This only fires on `InputHook.IS_ACTION_TRIGGERED` (1). */
-  MUTE = 18,
+  /**
+   * This only fires on `InputHook.IS_ACTION_TRIGGERED` (1).
+   *
+   * This enum value changed in Repentance+ from 17 to 16.
+   */
+  FULLSCREEN_REPENTANCE = 17,
+
+  /**
+   * This only fires on `InputHook.IS_ACTION_TRIGGERED` (1).
+   *
+   * This enum value changed in Repentance+ from 18 to 17.
+   */
+  // eslint-disable-next-line @typescript-eslint/no-duplicate-enum-values
+  MUTE_REPENTANCE_PLUS = 17,
+
+  /**
+   * This only fires on `InputHook.IS_ACTION_TRIGGERED` (1).
+   *
+   * This enum value changed in Repentance+ from 18 to 17.
+   */
+  MUTE_REPENTANCE = 18,
+
+  /**
+   * This only fires on `InputHook.IS_ACTION_PRESSED` (0).
+   *
+   * This enum value changed in Repentance+ from 16 to 18.
+   */
+  // eslint-disable-next-line @typescript-eslint/no-duplicate-enum-values
+  RESTART_REPENTANCE_PLUS = 18,
 
   /** Does not seem to trigger any input hooks while on keyboard. */
   JOIN_MULTIPLAYER = 19,
@@ -76,15 +112,63 @@ export enum ButtonAction {
   /** Does not seem to trigger any input hooks while on keyboard. */
   MENU_DOWN = 23,
 
-  /** Does not seem to trigger any input hooks while on keyboard. */
-  MENU_LT = 24,
+  /** This enum value changed in Repentance+ from 24 to 26. */
+  MENU_LEFT_TRIGGER_REPENTANCE = 24,
 
-  /** Does not seem to trigger any input hooks while on keyboard. */
-  MENU_RT = 25,
+  /** Added in Repentance+. (It took the old value for "MENU_LEFT_TRIGGER".) */
+  // eslint-disable-next-line @typescript-eslint/no-duplicate-enum-values
+  MENU_LEFT_SHOULDER = 24,
 
-  /** Does not seem to trigger any input hooks while on keyboard. */
-  MENU_TAB = 26,
+  /** This enum value changed in Repentance+ from 25 to 27. */
+  MENU_RIGHT_TRIGGER_REPENTANCE = 25,
 
-  /** This only fires on `InputHook.IS_ACTION_TRIGGERED` (1). */
-  CONSOLE = 28,
+  /** Added in Repentance+. (It took the old value for "MENU_RIGHT_TRIGGER".) */
+  // eslint-disable-next-line @typescript-eslint/no-duplicate-enum-values
+  MENU_RIGHT_SHOULDER = 25,
+
+  /** This enum value changed in Repentance+ from 26 to 28. */
+  MENU_TAB_REPENTANCE = 26,
+
+  /**
+   * Does not seem to trigger any input hooks while on keyboard.
+   *
+   * This enum value changed in Repentance+ from 24 to 26.
+   */
+  // eslint-disable-next-line @typescript-eslint/no-duplicate-enum-values
+  MENU_LEFT_TRIGGER_REPENTANCE_PLUS = 26,
+
+  /**
+   * Does not seem to trigger any input hooks while on keyboard.
+   *
+   * This enum value changed in Repentance+ from 25 to 27.
+   */
+  MENU_RIGHT_TRIGGER_REPENTANCE_PLUS = 27,
+
+  /**
+   * This only fires on `InputHook.IS_ACTION_TRIGGERED` (1).
+   *
+   * This enum value changed in Repentance+ from 28 to 32.
+   */
+  CONSOLE_REPENTANCE = 28,
+
+  /**
+   * Does not seem to trigger any input hooks while on keyboard.
+   *
+   * This enum value changed in Repentance+ from 26 to 28.
+   */
+  // eslint-disable-next-line @typescript-eslint/no-duplicate-enum-values
+  MENU_TAB_REPENTANCE_PLUS = 28,
+
+  /** Added in Repentance+. */
+  MENU_EX = 29,
+
+  /** Added in Repentance+. */
+  EMOTES = 30,
+
+  /**
+   * This only fires on `InputHook.IS_ACTION_TRIGGERED` (1).
+   *
+   * This enum value changed in Repentance+ from 28 to 32.
+   */
+  CONSOLE_REPENTANCE_PLUS = 32,
 }
diff --git a/packages/isaac-typescript-definitions/src/enums/DrawStringAlignment.ts b/packages/isaac-typescript-definitions/src/enums/DrawStringAlignment.ts
new file mode 100644
index 000000000..64e4eaa0d
--- /dev/null
+++ b/packages/isaac-typescript-definitions/src/enums/DrawStringAlignment.ts
@@ -0,0 +1,12 @@
+/** Added in Repentance+. */
+export enum DrawStringAlignment {
+  TOP_LEFT = 0,
+  TOP_CENTER = 1,
+  TOP_RIGHT = 2,
+  MIDDLE_LEFT = 3,
+  MIDDLE_CENTER = 4,
+  MIDDLE_RIGHT = 5,
+  BOTTOM_LEFT = 6,
+  BOTTOM_CENTER = 7,
+  BOTTOM_RIGHT = 8,
+}
diff --git a/packages/isaac-typescript-definitions/src/enums/GameStateFlag.ts b/packages/isaac-typescript-definitions/src/enums/GameStateFlag.ts
index 376dd1b38..21722277b 100644
--- a/packages/isaac-typescript-definitions/src/enums/GameStateFlag.ts
+++ b/packages/isaac-typescript-definitions/src/enums/GameStateFlag.ts
@@ -97,4 +97,16 @@ export enum GameStateFlag {
 
   /** Set when the player takes Dad's Note. The "backwards path" refers to the Ascent. */
   BACKWARDS_PATH = 48,
+
+  /** Added in Repentance+. */
+  MEGA_SATAN_DOOR_OPENED = 49,
+
+  /** Added in Repentance+. */
+  URIEL_KILLED = 50,
+
+  /** Added in Repentance+. */
+  GABRIEL_KILLED = 51,
+
+  /** Added in Repentance+. */
+  MOTHER_HEART_DOOR_OPENED = 52,
 }
diff --git a/packages/isaac-typescript-definitions/src/enums/GridRoom.ts b/packages/isaac-typescript-definitions/src/enums/GridRoom.ts
index 1a97e8304..363af2420 100644
--- a/packages/isaac-typescript-definitions/src/enums/GridRoom.ts
+++ b/packages/isaac-typescript-definitions/src/enums/GridRoom.ts
@@ -61,4 +61,10 @@ export enum GridRoom {
 
   /** The shop that you go to when you climb the ladder from The Stairway. */
   ANGEL_SHOP = -18,
+
+  /** Added in Repentance+. */
+  DEATHMATCH = -19,
+
+  /** Added in Repentance+. */
+  LIL_PORTAL = -20,
 }
diff --git a/packages/isaac-typescript-definitions/src/enums/JacobEsauControls.ts b/packages/isaac-typescript-definitions/src/enums/JacobEsauControls.ts
new file mode 100644
index 000000000..586ae7aed
--- /dev/null
+++ b/packages/isaac-typescript-definitions/src/enums/JacobEsauControls.ts
@@ -0,0 +1,5 @@
+/** Added in Repentance+. */
+export enum JacobEsauControls {
+  CLASSIC = 0,
+  BETTER = 1,
+}
diff --git a/packages/isaac-typescript-definitions/src/enums/Music.ts b/packages/isaac-typescript-definitions/src/enums/Music.ts
index 1ada559bc..8ca5598a8 100644
--- a/packages/isaac-typescript-definitions/src/enums/Music.ts
+++ b/packages/isaac-typescript-definitions/src/enums/Music.ts
@@ -97,4 +97,7 @@ export enum Music {
   MINESHAFT_AMBIENT = 116,
   MINESHAFT_ESCAPE = 117,
   REVERSE_GENESIS = 118,
+
+  /** Added in Repentance+. */
+  MUSIC_DEATHMATCH = 119,
 }
diff --git a/packages/isaac-typescript-definitions/src/enums/RoomType.ts b/packages/isaac-typescript-definitions/src/enums/RoomType.ts
index ef481b2f5..f74a7d40e 100644
--- a/packages/isaac-typescript-definitions/src/enums/RoomType.ts
+++ b/packages/isaac-typescript-definitions/src/enums/RoomType.ts
@@ -50,4 +50,7 @@ export enum RoomType {
   BLUE = 28,
 
   ULTRA_SECRET = 29,
+
+  /** Added in Repentance+. */
+  DEATHMATCH = 30,
 }
diff --git a/packages/isaac-typescript-definitions/src/enums/SoundEffect.ts b/packages/isaac-typescript-definitions/src/enums/SoundEffect.ts
index a8c0afd4d..78dfee289 100644
--- a/packages/isaac-typescript-definitions/src/enums/SoundEffect.ts
+++ b/packages/isaac-typescript-definitions/src/enums/SoundEffect.ts
@@ -827,4 +827,778 @@ export enum SoundEffect {
   G_FUEL_GUNSHOT_MINI = 830,
   G_FUEL_BULLET_RICOCHET = 831,
   G_FUEL_ROCKET_LAUNCHER = 832,
+
+  /** Added in Repentance+. */
+  DEATHMATCH_INTRO = 833,
+
+  /** Added in Repentance+. */
+  ABYSS = 834,
+
+  /** Added in Repentance+. */
+  BIG_CHUBBY_ATTACK = 835,
+
+  /** Added in Repentance+. */
+  BOOMERANG_THROW = 836,
+
+  /** Added in Repentance+. */
+  BOOMERANG_LOOP = 837,
+
+  /** Added in Repentance+. */
+  BOOMERANG_CATCH = 838,
+
+  /** Added in Repentance+. */
+  BOOMERANG_HIT = 839,
+
+  /** Added in Repentance+. */
+  BOX_OF_FRIENDS = 840,
+
+  /** Added in Repentance+. */
+  BROWN_NUGGET = 841,
+
+  /** Added in Repentance+. */
+  BUMBO_1 = 842,
+
+  /** Added in Repentance+. */
+  BUMBO_2 = 843,
+
+  /** Added in Repentance+. */
+  BUMBO_3 = 844,
+
+  /** Added in Repentance+. */
+  BUMBO_4 = 845,
+
+  /** Added in Repentance+. */
+  PORTAL_ENTITY_LOOP = 846,
+
+  /** Added in Repentance+. */
+  PORTAL_ENTITY_ENTER = 847,
+
+  /** Added in Repentance+. */
+  CONVERTER = 848,
+
+  /** Added in Repentance+. */
+  LITTLE_CHUBBY_ATTACK = 849,
+
+  /** Added in Repentance+. */
+  CRACKED_ORB = 850,
+
+  /** Added in Repentance+. */
+  CROOKED_PENNY = 851,
+
+  /** Added in Repentance+. */
+  CUBE_BABY_KICK = 852,
+
+  /** Added in Repentance+. */
+  DARK_BUM_PAYOUT = 853,
+
+  /** Added in Repentance+. */
+  DATAMINER = 854,
+
+  /** Added in Repentance+. */
+  DR_REMOTE_WARNING = 855,
+
+  /** Added in Repentance+. */
+  FLIP_POOF = 856,
+
+  /** Added in Repentance+. */
+  ERASER_HIT = 857,
+
+  /** Added in Repentance+. */
+  GNAWED_LEAF = 858,
+
+  /** Added in Repentance+. */
+  LIL_HAUNT_CHASE = 859,
+
+  /** Added in Repentance+. */
+  LINGER_BEAN = 860,
+
+  /** Added in Repentance+. */
+  GLOWING_HOURGLASS_ACTIVATE = 861,
+
+  /** Added in Repentance+. */
+  GLOWING_HOURGLASS_FIZZLE = 862,
+
+  /** Added in Repentance+. */
+  INFAMY_DEFLECT = 863,
+
+  /** Added in Repentance+. */
+  IBS_GURGLE = 864,
+
+  /** Added in Repentance+. */
+  POOP_THROW = 865,
+
+  /** Added in Repentance+. */
+  GLITTER_BOOM = 866,
+
+  /** Added in Repentance+. */
+  GLITTER_FUSE = 867,
+
+  /** Added in Repentance+. */
+  LITTLE_HORN_SHOOT = 868,
+
+  /** Added in Repentance+. */
+  MEGA_BEAN_BLAST = 869,
+
+  /** Added in Repentance+. */
+  MOM_BOTTLE = 870,
+
+  /** Added in Repentance+. */
+  SUMMON_PENTAGRAM = 871,
+
+  /** Added in Repentance+. */
+  SUMMON_WAVE = 872,
+
+  /** Added in Repentance+. */
+  BIGHORN_APPEAR = 873,
+
+  /** Added in Repentance+. */
+  BIGHORN_CLOSE_BIG = 874,
+
+  /** Added in Repentance+. */
+  BIGHORN_CRACK_BIG = 875,
+
+  /** Added in Repentance+. */
+  BIGHORN_OPEN_BIG = 876,
+
+  /** Added in Repentance+. */
+  BIGHORN_SHAKE_BIG = 877,
+
+  /** Added in Repentance+. */
+  BIGHORN_DEATH = 878,
+
+  /** Added in Repentance+. */
+  BIGHORN_DIZZY_SHAKE = 879,
+
+  /** Added in Repentance+. */
+  BIGHORN_HAND_APPEAR = 880,
+
+  /** Added in Repentance+. */
+  BIGHORN_HAND_HIDE = 881,
+
+  /** Added in Repentance+. */
+  BIGHORN_HIDE = 882,
+
+  /** Added in Repentance+. */
+  BIGHORN_HURT = 883,
+
+  /** Added in Repentance+. */
+  BIGHORN_PRE_SPIT = 884,
+
+  /** Added in Repentance+. */
+  BIGHORN_CLOSE_SMALL = 885,
+
+  /** Added in Repentance+. */
+  BIGHORN_CRACK_SMALL = 886,
+
+  /** Added in Repentance+. */
+  BIGHORN_OPEN_SMALL = 887,
+
+  /** Added in Repentance+. */
+  BIGHORN_SHAKE_SMALL = 888,
+
+  /** Added in Repentance+. */
+  BIGHORN_SPIT = 889,
+
+  /** Added in Repentance+. */
+  MOMS_BOX = 890,
+
+  /** Added in Repentance+. */
+  MONSTRO_LUNG_BARF = 891,
+
+  /** Added in Repentance+. */
+  MOVING_BOX_PACK = 892,
+
+  /** Added in Repentance+. */
+  MOVING_BOX_UNPACK = 893,
+
+  /** Added in Repentance+. */
+  PANDORAS_BOX = 894,
+
+  /** Added in Repentance+. */
+  PAUSE_FREEZE = 895,
+
+  /** Added in Repentance+. */
+  MONSTRO_LUNG_CHARGE = 896,
+
+  /** Added in Repentance+. */
+  PLAN_C = 897,
+
+  /** Added in Repentance+. */
+  PORTABLE_SLOT_USE = 898,
+
+  /** Added in Repentance+. */
+  PORTABLE_SLOT_WIN = 899,
+
+  /** Added in Repentance+. */
+  SAFETY_SCISSORS = 900,
+
+  /** Added in Repentance+. */
+  BUTTER_DROP = 901,
+
+  /** Added in Repentance+. */
+  BUTTER_LAND = 902,
+
+  /** Added in Repentance+. */
+  PRIDE_ZAP = 903,
+
+  /** Added in Repentance+. */
+  R_KEY = 904,
+
+  /** Added in Repentance+. */
+  TEAR_BOUNCE = 905,
+
+  /** Added in Repentance+. */
+  SHARP_PLUG = 906,
+
+  /** Added in Repentance+. */
+  RIB_DEFLECT = 907,
+
+  /** Added in Repentance+. */
+  SMELTER = 908,
+
+  // cspell:disable-next-line-next-line
+  /** Added in Repentance+. Note that the vanilla enum is incorrectly spelled as "TELEKENESIS". */
+  TELEKINESIS = 909,
+
+  /** Added in Repentance+. */
+  // eslint-disable-next-line isaacscript/enum-member-number-separation
+  D6_ROLL = 910,
+
+  /** Added in Repentance+. */
+  TICK_BURN = 911,
+
+  /** Added in Repentance+. */
+  TELEPORT_UNDEFINED = 912,
+
+  /** Added in Repentance+. */
+  VOID_CONSUME = 913,
+
+  /** Added in Repentance+. */
+  YO_LISTEN = 914,
+
+  /** Added in Repentance+. */
+  SPIN_TO_WIN = 915,
+
+  /** Added in Repentance+. */
+  SHOVEL_DIG_2 = 916,
+
+  /** Added in Repentance+. */
+  SHOVEL_HOLE_OPEN = 917,
+
+  /** Added in Repentance+. */
+  CAGE_DEATH = 918,
+
+  /** Added in Repentance+. */
+  CAGE_JUMP = 919,
+
+  /** Added in Repentance+. */
+  CAGE_RIBS = 920,
+
+  /** Added in Repentance+. */
+  CAGE_ROLL_START = 921,
+
+  /** Added in Repentance+. */
+  CAGE_PREP_SHOOT = 922,
+
+  /** Added in Repentance+. */
+  CAGE_ROLL_STOP = 923,
+
+  /** Added in Repentance+. */
+  CAGE_ROLL_BOUNCE = 924,
+
+  /** Added in Repentance+. */
+  DEATH_HOURGLASS = 925,
+
+  /** Added in Repentance+. */
+  DEATH_SICKLE = 926,
+
+  /** Added in Repentance+. */
+  DEATH_LEAN = 927,
+
+  /** Added in Repentance+. */
+  DEATH_VOX = 928,
+
+  /** Added in Repentance+. */
+  DEATH_SPAWN_PREP = 929,
+
+  /** Added in Repentance+. */
+  DEATH_HORSE_ATTACK = 930,
+
+  /** Added in Repentance+. */
+  DEATH_HORSE_WOOSH = 931,
+
+  /** Added in Repentance+. */
+  PIN_DIVE = 932,
+
+  /** Added in Repentance+. */
+  PIN_POPUP = 933,
+
+  /** Added in Repentance+. */
+  PIN_PUDDLE = 934,
+
+  /** Added in Repentance+. */
+  PIN_SPIT = 935,
+
+  /** Added in Repentance+. */
+  GISH_JUMP = 936,
+
+  /** Added in Repentance+. */
+  GISH_JUMP_HIGH = 937,
+
+  /** Added in Repentance+. */
+  GISH_SPIT = 938,
+
+  /** Added in Repentance+. */
+  GURDY_FACE_ATTACK_APPEAR = 939,
+
+  /** Added in Repentance+. */
+  GURDY_FACE_ATTACK_HIDE = 940,
+
+  /** Added in Repentance+. */
+  GURDY_FACE_SMILE_APPEAR = 941,
+
+  /** Added in Repentance+. */
+  GURDY_FACE_SMILE_HIDE = 942,
+
+  /** Added in Repentance+. */
+  GURGLING_ATTACK = 943,
+
+  /** Added in Repentance+. */
+  LITTLE_HORN_DEATH = 944,
+
+  /** Added in Repentance+. */
+  LITTLE_HORN_BOMB_DROP = 945,
+
+  /** Added in Repentance+. */
+  LITTLE_HORN_DIVE = 946,
+
+  /** Added in Repentance+. */
+  LITTLE_HORN_HOLE_OPEN = 947,
+
+  /** Added in Repentance+. */
+  LITTLE_HORN_HOLE_EXIT = 948,
+
+  /** Added in Repentance+. */
+  LOKI_GIGGLE = 949,
+
+  /** Added in Repentance+. */
+  LOKI_JUMP_OUT = 950,
+
+  /** Added in Repentance+. */
+  LOKI_JUMP_IN = 951,
+
+  /** Added in Repentance+. */
+  LOKI_SHOOT = 952,
+
+  /** Added in Repentance+. */
+  LOKI_SHOOT_8 = 953,
+
+  /** Added in Repentance+. */
+  MASK_INFAMY_MAD = 954,
+
+  /** Added in Repentance+. */
+  MASK_INFAMY_DASH = 955,
+
+  /** Added in Repentance+. */
+  MEGA_FATTY_GULP = 956,
+
+  /** Added in Repentance+. */
+  MEGA_FATTY_SUCKING = 957,
+
+  /** Added in Repentance+. */
+  MEGA_FATTY_VOMIT = 958,
+
+  /** Added in Repentance+. */
+  STAIN_ATTACK_VOX = 959,
+
+  /** Added in Repentance+. */
+  SISTERS_VIS_SCARE = 960,
+
+  /** Added in Repentance+. */
+  STEVEN_DEATH_BIG = 961,
+
+  /** Added in Repentance+. */
+  STEVEN_DEATH_SMALL = 963,
+
+  /** Added in Repentance+. */
+  FALLEN_FLAP_CHASE = 964,
+
+  /** Added in Repentance+. */
+  FALLEN_GROWL = 965,
+
+  /** Added in Repentance+. */
+  FALLEN_FLAP = 966,
+
+  /** Added in Repentance+. */
+  FALLEN_OPEN_WINGS = 967,
+
+  /** Added in Repentance+. */
+  TERATOMA_BOUNCE_BIG = 968,
+
+  /** Added in Repentance+. */
+  TERATOMA_BOUNCE_MEDIUM = 969,
+
+  /** Added in Repentance+. */
+  TERATOMA_BOUNCE_SMALL = 970,
+
+  /** Added in Repentance+. */
+  FORSAKEN_LASER = 971,
+
+  /** Added in Repentance+. */
+  FORSAKEN_ARMS_UP = 972,
+
+  /** Added in Repentance+. */
+  FORSAKEN_FADE = 973,
+
+  /** Added in Repentance+. */
+  FISTULA_BOUNCE_LARGE = 974,
+
+  /** Added in Repentance+. */
+  FISTULA_BOUNCE_MEDIUM = 975,
+
+  /** Added in Repentance+. */
+  FISTULA_BOUNCE_SMALL = 976,
+
+  /** Added in Repentance+. */
+  FISTULA_BURST_LARGE = 977,
+
+  /** Added in Repentance+. */
+  FISTULA_GROWL_LARGE = 978,
+
+  /** Added in Repentance+. */
+  FISTULA_GROWL_MEDIUM = 979,
+
+  /** Added in Repentance+. */
+  FISTULA_GROWL_SMALL = 980,
+
+  /** Added in Repentance+. */
+  RAG_MEGA_BALL_ATTACK = 981,
+
+  /** Added in Repentance+. */
+  RAG_MEGA_BEAM = 982,
+
+  /** Added in Repentance+. */
+  RAG_MEGA_INHALE = 983,
+
+  /** Added in Repentance+. */
+  RAG_MEGA_EXHALE = 984,
+
+  /** Added in Repentance+. */
+  RAG_MEGA_INVINCIBLE_ON = 985,
+
+  /** Added in Repentance+. */
+  RAG_MEGA_INVINCIBLE_OFF = 986,
+
+  /** Added in Repentance+. */
+  BLASTOCYST_JUMP_BIG = 987,
+
+  /** Added in Repentance+. */
+  BLASTOCYST_JUMP = 988,
+
+  /** Added in Repentance+. */
+  BLASTOCYST_JUMP_SMALL = 989,
+
+  /** Added in Repentance+. */
+  POOP_DROP = 990,
+
+  /** Added in Repentance+. */
+  CARRION_QUEEN_BOUNCE = 991,
+
+  /** Added in Repentance+. */
+  CARRION_QUEEN_DIAGONAL_START = 992,
+
+  /** Added in Repentance+. */
+  CARRION_QUEEN_DIAGONAL_VOX = 993,
+
+  /** Added in Repentance+. */
+  CARRION_QUEEN_ROAR = 994,
+
+  /** Added in Repentance+. */
+  HAUNT_CHARGE = 995,
+
+  /** Added in Repentance+. */
+  HAUNT_DEATH = 996,
+
+  /** Added in Repentance+. */
+  HAUNT_ROAR = 997,
+
+  /** Added in Repentance+. */
+  HAUNT_RELEASE_LIL = 998,
+
+  /** Added in Repentance+. */
+  LARRY_JR_DEATH_1 = 999,
+
+  /** Added in Repentance+. */
+  LARRY_JR_DEATH_2 = 1000,
+
+  /** Added in Repentance+. */
+  LARRY_JR_ROAR = 1001,
+
+  /** Added in Repentance+. */
+  MEGA_FATTY_MEGA_FART = 1002,
+
+  /** Added in Repentance+. */
+  HOLLOW_DEATH_1 = 1003,
+
+  /** Added in Repentance+. */
+  HOLLOW_DEATH_2 = 1004,
+
+  /** Added in Repentance+. */
+  HOLLOW_ROAR = 1005,
+
+  /** Added in Repentance+. */
+  WAR_KNOCKDOWN = 1006,
+
+  /** Added in Repentance+. */
+  WAR_CHARGE = 1007,
+
+  /** Added in Repentance+. */
+  BOSS_NEAR = 1008,
+
+  /** Added in Repentance+. */
+  CAMBION_CONCEPTION = 1009,
+
+  /** Added in Repentance+. */
+  IMMACULATE_CONCEPTION = 1010,
+
+  /** Added in Repentance+. */
+  CHARGED_BABY_BATTERY = 1011,
+
+  /** Added in Repentance+. */
+  CHARGED_BABY_CHARGE = 1012,
+
+  /** Added in Repentance+. */
+  CHARGED_BABY_STUN = 1013,
+
+  /** Added in Repentance+. */
+  ROCK_SHINE = 1014,
+
+  /** Added in Repentance+. */
+  BLUE_SPIDER_DIE = 1015,
+
+  /** Added in Repentance+. */
+  SISSY_LONGLEGS_CHARM = 1016,
+
+  /** Added in Repentance+. */
+  ITEM_RAISE = 1017,
+
+  /** Added in Repentance+. */
+  CLOG_POOP_SMOKE = 1018,
+
+  /** Added in Repentance+. */
+  FRIENDLY_BALL_CAPTURE = 1019,
+
+  /** Added in Repentance+. */
+  FRIENDLY_BALL_LAND = 1020,
+
+  /** Added in Repentance+. */
+  FRIENDLY_BALL_PICKUP = 1021,
+
+  /** Added in Repentance+. */
+  FRIENDLY_BALL_RAISE = 1022,
+
+  /** Added in Repentance+. */
+  FRIENDLY_BALL_RELEASE = 1023,
+
+  /** Added in Repentance+. */
+  FRIENDLY_BALL_THROW = 1024,
+
+  /** Added in Repentance+. */
+  BEST_FRIEND = 1025,
+
+  /** Added in Repentance+. */
+  BOOK_SHADOWS_START = 1026,
+
+  /** Added in Repentance+. */
+  BOOK_SHADOWS_END = 1027,
+
+  /** Added in Repentance+. */
+  BOOK_SHADOWS_SIGIL = 1028,
+
+  /** Added in Repentance+. */
+  BOX_SPIDERS = 1029,
+
+  /** Added in Repentance+. */
+  SUPLEX_ACTIVATE = 1030,
+
+  /** Added in Repentance+. */
+  SUPLEX_GRAB = 1031,
+
+  /** Added in Repentance+. */
+  SUPLEX_JUMP = 1032,
+
+  /** Added in Repentance+. */
+  SUPLEX_LAND = 1033,
+
+  /** Added in Repentance+. */
+  DEAD_SEA_SCROLLS = 1034,
+
+  /** Added in Repentance+. */
+  MOMS_BRA = 1035,
+
+  /** Added in Repentance+. */
+  RED_CANDLE = 1036,
+
+  /** Added in Repentance+. */
+  SATANIC_BIBLE = 1037,
+
+  /** Added in Repentance+. */
+  BIBLE = 1038,
+
+  /** Added in Repentance+. */
+  HOURGLASS = 1039,
+
+  /** Added in Repentance+. */
+  MEGA_MUSH_SHRINK = 1040,
+
+  /** Added in Repentance+. */
+  MAGIC_SKIN = 1041,
+
+  /** Added in Repentance+. */
+  BOOK_OF_SIN = 1042,
+
+  /** Added in Repentance+. */
+  BROKEN_SHOVEL = 1043,
+
+  /** Added in Repentance+. */
+  DULL_RAZOR = 1044,
+
+  /** Added in Repentance+. */
+  DARK_ARTS = 1045,
+
+  /** Added in Repentance+. */
+  DECAP_ACTIVATE = 1046,
+
+  // cspell:disable-next-line
+  /** Added in Repentance+. */
+  DECAP_THROW = 1047,
+
+  /** Added in Repentance+. */
+  ESAU_JR = 1048,
+
+  /** Added in Repentance+. */
+  NECROMANCER = 1049,
+
+  /** Added in Repentance+. */
+  GELLO = 1050,
+
+  /** Added in Repentance+. */
+  HEAVENS_DOOR_ENTER = 1051,
+
+  /** Added in Repentance+. */
+  TRAP_DOOR_LEVEL = 1052,
+
+  /** Added in Repentance+. */
+  CRYSTAL_BALL = 1053,
+
+  /** Added in Repentance+. */
+  FORGET_ME_NOW = 1054,
+
+  /** Added in Repentance+. */
+  HOW_TO_JUMP = 1055,
+
+  /** Added in Repentance+. */
+  IV_BAG = 1056,
+
+  /** Added in Repentance+. */
+  NOTCHED_AXE = 1057,
+
+  /** Added in Repentance+. */
+  RAZOR_BLADE = 1058,
+
+  /** Added in Repentance+. */
+  TELEPATHY_DUMMY = 1059,
+
+  /** Added in Repentance+. */
+  JAR_OF_FLIES = 1060,
+
+  /** Added in Repentance+. */
+  DIPLOPIA = 1061,
+
+  /** Added in Repentance+. */
+  MINE_CRAFTER = 1062,
+
+  /** Added in Repentance+. */
+  TEAR_DETONATOR = 1063,
+
+  /** Added in Repentance+. */
+  VENTRICLE_RAZOR = 1064,
+
+  /** Added in Repentance+. */
+  WOODEN_NICKEL = 1065,
+
+  /** Added in Repentance+. */
+  WOODEN_NICKEL_SPAWN = 1066,
+
+  /** Added in Repentance+. */
+  BLACK_HOLE_ACTIVATE = 1067,
+
+  /** Added in Repentance+. */
+  BLACK_HOLE_THROW = 1068,
+
+  /** Added in Repentance+. */
+  MR_ME = 1069,
+
+  /** Added in Repentance+. */
+  SPRINKLER_SPAWN = 1070,
+
+  /** Added in Repentance+. */
+  VOID_SUCCESS = 1071,
+
+  /** Added in Repentance+. */
+  VOID_FAIL = 1072,
+
+  /** Added in Repentance+. */
+  ABYSS_SUCCESS = 1073,
+
+  /** Added in Repentance+. */
+  BAG_OF_CRAFTING = 1074,
+
+  /** Added in Repentance+. */
+  GIANT_CHEST_OPEN = 1075,
+
+  /** Added in Repentance+. */
+  IMP_GROWL = 1076,
+
+  /** Added in Repentance+. */
+  IMP_SHOOT = 1077,
+
+  /** Added in Repentance+. */
+  IMP_WARP_OUT = 1078,
+
+  /** Added in Repentance+. */
+  IMP_WARP_IN = 1079,
+
+  /** Added in Repentance+. */
+  BRAIN_MOVE = 1080,
+
+  /** Added in Repentance+. */
+  POISON_MIND_HURT = 1081,
+
+  /** Added in Repentance+. */
+  KNIGHT_GROWL = 1082,
+
+  /** Added in Repentance+. */
+  SELFLESS_KNIGHT_GROWL = 1083,
+
+  /** Added in Repentance+. */
+  FLOATING_KNIGHT_GROWL = 1084,
+
+  /** Added in Repentance+. */
+  BUTTLICKER_GROWL = 1085,
+
+  /** Added in Repentance+. */
+  LADDER = 1086,
+
+  /** Added in Repentance+. */
+  OCULAR_RIFT_SHOOT = 1087,
+
+  /** Added in Repentance+. */
+  OCULAR_RIFT_PORTAL = 1088,
+
+  /** Added in Repentance+. */
+  UNBORN_GROWL = 1089,
+
+  /** Added in Repentance+. */
+  UNBORN_WARP = 1090,
 }
diff --git a/packages/isaac-typescript-definitions/src/enums/collections/variants.ts b/packages/isaac-typescript-definitions/src/enums/collections/variants.ts
index 1f57eb50d..1cbf28fb8 100644
--- a/packages/isaac-typescript-definitions/src/enums/collections/variants.ts
+++ b/packages/isaac-typescript-definitions/src/enums/collections/variants.ts
@@ -1636,4 +1636,19 @@ export enum EffectVariant {
   DEAD_BIRD = 197,
   GENERIC_TRACER = 198,
   ULTRA_DEATH_SCYTHE = 199,
+
+  /** Added in Repentance+. */
+  BULLET_POOF_STATIC = 200,
+
+  /** Added in Repentance+. */
+  UMBILICAL_CORD_HELPER = 201,
+
+  /** Added in Repentance+. */
+  MEGA_BEAN_EXPLOSION = 202,
+
+  /** Added in Repentance+. */
+  SPAWN_PENTAGRAM = 203,
+
+  /** Added in Repentance+. */
+  PLAYER_CREEP_YELLOW = 204,
 }
diff --git a/packages/isaac-typescript-definitions/src/index.ts b/packages/isaac-typescript-definitions/src/index.ts
index 9b075971f..8134e48ff 100644
--- a/packages/isaac-typescript-definitions/src/index.ts
+++ b/packages/isaac-typescript-definitions/src/index.ts
@@ -27,6 +27,7 @@ export * from "./enums/Difficulty";
 export * from "./enums/Dimension";
 export * from "./enums/Direction";
 export * from "./enums/DoorSlot";
+export * from "./enums/DrawStringAlignment";
 export * from "./enums/EntityCollisionClass";
 export * from "./enums/EntityGridCollisionClass";
 export * from "./enums/EntityType";
@@ -59,6 +60,7 @@ export * from "./enums/ItemConfigPillEffectClass";
 export * from "./enums/ItemConfigPillEffectType";
 export * from "./enums/ItemPoolType";
 export * from "./enums/ItemType";
+export * from "./enums/JacobEsauControls";
 export * from "./enums/Keyboard";
 export * from "./enums/LanguageAbbreviation";
 export * from "./enums/LaserOffset";
diff --git a/packages/isaac-typescript-definitions/src/types/classes/Entity.d.ts b/packages/isaac-typescript-definitions/src/types/classes/Entity.d.ts
index bbd51a1c9..82c395131 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/Entity.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/Entity.d.ts
@@ -17,8 +17,14 @@ declare global {
      * @param duration The number of frames that the effect should apply for. The minimum is 2
      *                 frames.
      * @param damage The damage taken per tick. Each damage tick is 20 frames apart.
+     * @param ignoreBosses Optional. Defaults to false. This parameter was added in Repentance+.
      */
-    AddBurn: (source: EntityRef, duration: int, damage: float) => void;
+    AddBurn: (
+      source: EntityRef,
+      duration: int,
+      damage: float,
+      ignoreBosses?: boolean,
+    ) => void;
 
     /**
      * Adds a charmed effect to the entity.
@@ -27,8 +33,13 @@ declare global {
      *               `EntityRef(undefined)`.
      * @param duration The number of frames that the effect should apply for. If set to -1, the
      *                 effect will be permanent and the entity will follow you to different rooms.
+     * @param ignoreBosses Optional. Defaults to false. This parameter was added in Repentance+.
      */
-    AddCharmed: (source: EntityRef, duration: int) => void;
+    AddCharmed: (
+      source: EntityRef,
+      duration: int,
+      ignoreBosses?: boolean,
+    ) => void;
 
     /**
      * Adds a confusion effect to the entity.
@@ -36,12 +47,12 @@ declare global {
      * @param source Required. If you do not want the effect to have a source, pass
      *               `EntityRef(undefined)`.
      * @param duration The number of frames that the effect should apply for. The maximum is 150.
-     * @param ignoreBosses
+     * @param ignoreBosses Optional. Defaults to false. This parameter was added in Repentance+.
      */
     AddConfusion: (
       source: EntityRef,
       duration: int,
-      ignoreBosses: boolean,
+      ignoreBosses?: boolean,
     ) => void;
 
     /**
@@ -56,8 +67,9 @@ declare global {
      * @param source Required. If you do not want the effect to have a source, pass
      *               `EntityRef(undefined)`.
      * @param duration The number of frames that the effect should apply for. The maximum is 150.
+     * @param ignoreBosses Optional. Defaults to false. This parameter was added in Repentance+.
      */
-    AddFear: (source: EntityRef, duration: int) => void;
+    AddFear: (source: EntityRef, duration: int, ignoreBosses?: boolean) => void;
 
     /**
      * Adds a freeze effect to the entity.
@@ -65,8 +77,13 @@ declare global {
      * @param source Required. If you do not want the effect to have a source, pass
      *               `EntityRef(undefined)`.
      * @param duration The number of frames that the effect should apply for. The maximum is 150.
+     * @param ignoreBosses Optional. Defaults to false. This parameter was added in Repentance+.
      */
-    AddFreeze: (source: EntityRef, duration: int) => void;
+    AddFreeze: (
+      source: EntityRef,
+      duration: int,
+      ignoreBosses?: boolean,
+    ) => void;
 
     /** Heals the entity. */
     AddHealth: (hitPoints: float) => void;
@@ -80,8 +97,13 @@ declare global {
      * @param duration The number of frames that the effect should apply for. The maximum is 150.
      *                 (However, if a value higher than 150 is passed, the freeze will be reduced to
      *                 150 frames, but the gold color will persist for the full duration.)
+     * @param ignoreBosses Optional. Defaults to false. This parameter was added in Repentance+.
      */
-    AddMidasFreeze: (source: EntityRef, duration: int) => void;
+    AddMidasFreeze: (
+      source: EntityRef,
+      duration: int,
+      ignoreBosses?: boolean,
+    ) => void;
 
     /**
      * Adds a poison effect to the entity.
@@ -91,8 +113,14 @@ declare global {
      * @param duration The number of frames that the effect should apply for. The minimum is 2
      *                 frames. The maximum is 150.
      * @param damage The damage taken per tick. Each damage tick is 20 frames apart.
+     * @param ignoreBosses Optional. Defaults to false. This parameter was added in Repentance+.
      */
-    AddPoison: (source: EntityRef, duration: int, damage: float) => void;
+    AddPoison: (
+      source: EntityRef,
+      duration: int,
+      damage: float,
+      ignoreBosses?: boolean,
+    ) => void;
 
     /**
      * Adds a shrink effect to the entity.
@@ -100,8 +128,13 @@ declare global {
      * @param source Required. If you do not want the effect to have a source, pass
      *               `EntityRef(undefined)`.
      * @param duration The number of frames that the effect should apply for.
+     * @param ignoreBosses Optional. Defaults to false. This parameter was added in Repentance+.
      */
-    AddShrink: (source: EntityRef, duration: int) => void;
+    AddShrink: (
+      source: EntityRef,
+      duration: int,
+      ignoreBosses?: boolean,
+    ) => void;
 
     /**
      * Adds a slowing effect to the entity.
@@ -111,13 +144,15 @@ declare global {
      * @param duration The number of frames that the effect should apply for.
      * @param slowValue This is the multiplier applied to the entity's movement speed. For example,
      *                  a value of 0.5 would slow down the entity by 50%.
-     * @param slowColor
+     * @param slowColor The color modification to make to the enemy.
+     * @param ignoreBosses Optional. Defaults to false. This parameter was added in Repentance+.
      */
     AddSlowing: (
       source: EntityRef,
       duration: int,
       slowValue: float,
       slowColor: Color,
+      ignoreBosses?: boolean,
     ) => void;
 
     /**
@@ -219,6 +254,10 @@ declare global {
     IsVulnerableEnemy: () => boolean;
 
     Kill: () => void;
+
+    /** Added in Repentance+. */
+    KillWithSource: (source: EntityRef) => void;
+
     MultiplyFriction: (value: float) => void;
     PostRender: () => void;
     Remove: () => void;
diff --git a/packages/isaac-typescript-definitions/src/types/classes/EntityPlayer.d.ts b/packages/isaac-typescript-definitions/src/types/classes/EntityPlayer.d.ts
index 8f42d1ef3..a5ca8e446 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/EntityPlayer.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/EntityPlayer.d.ts
@@ -20,6 +20,7 @@ import type { CacheFlag } from "../../enums/flags/CacheFlag";
 import type { DamageFlag } from "../../enums/flags/DamageFlag";
 import type { TearFlag } from "../../enums/flags/TearFlag";
 import type { UseFlag } from "../../enums/flags/UseFlag";
+import type { ItemPoolType } from "../../enums/ItemPoolType";
 import type { LaserOffset } from "../../enums/LaserOffset";
 import type { NullItemID } from "../../enums/NullItemID";
 import type { PillEffect } from "../../enums/PillEffect";
@@ -86,6 +87,7 @@ declare global {
      *                   `ActiveSlot.SLOT_PRIMARY`.
      * @param varData Sets the variable data for this collectible (this is used to store extra data
      *                for some active items like the number of uses for Jar of Wisps). Default is 0.
+     * @param itemPoolType This parameter was added in Repentance+.
      */
     AddCollectible: (
       collectibleType: CollectibleType,
@@ -93,6 +95,7 @@ declare global {
       firstTimePickingUp?: boolean,
       activeSlot?: ActiveSlot.PRIMARY | ActiveSlot.SECONDARY,
       varData?: int,
+      itemPoolType?: ItemPoolType,
     ) => void;
 
     AddControlsCooldown: (cooldown: int) => void;
diff --git a/packages/isaac-typescript-definitions/src/types/classes/Font.d.ts b/packages/isaac-typescript-definitions/src/types/classes/Font.d.ts
index 5c5067857..2f96815e9 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/Font.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/Font.d.ts
@@ -13,6 +13,8 @@ declare interface Font extends IsaacAPIClass {
    * - If `boxWidth` is not zero, and the `center` parameter is true, then the text will be centered
    *   inside the `boxWidth` size.
    *
+   * Repentance+ added a separate overload for drawing a string with a custom size.
+   *
    * @param str
    * @param positionX
    * @param positionY
@@ -20,14 +22,23 @@ declare interface Font extends IsaacAPIClass {
    * @param boxWidth Default is 0.
    * @param center Default is false.
    */
-  DrawString: (
+  DrawString: ((
     str: string,
     positionX: float,
     positionY: float,
     renderColor: KColor,
     boxWidth?: int,
     center?: boolean,
-  ) => void;
+  ) => void)
+    & ((
+      str: string,
+      positionX: float,
+      positionY: float,
+      sizeX: float,
+      sizeY: float,
+      renderColor: KColor,
+      fontRenderSettings: FontRenderSettings,
+    ) => void);
 
   /**
    * Converts UTF8 to UTF16, then draws the scaled string on the screen.
diff --git a/packages/isaac-typescript-definitions/src/types/classes/FontRenderSettings.d.ts b/packages/isaac-typescript-definitions/src/types/classes/FontRenderSettings.d.ts
new file mode 100644
index 000000000..9235a0757
--- /dev/null
+++ b/packages/isaac-typescript-definitions/src/types/classes/FontRenderSettings.d.ts
@@ -0,0 +1,26 @@
+import type { DrawStringAlignment } from "../../enums/DrawStringAlignment";
+
+declare global {
+  function FontRenderSettings(this: void): FontRenderSettings;
+
+  /** Added in Repentance+. */
+  interface FontRenderSettings extends IsaacAPIClass {
+    EnableAutoWrap: (enabled: boolean) => void;
+    EnableTruncation: (enabled: boolean) => void;
+    GetAlignment: () => DrawStringAlignment;
+    GetLineHeightModifier: () => float;
+    GetMaxCharacters: () => int;
+    GetMissingCharacterOverride: () => int;
+    IsAutoWrapEnabled: () => boolean;
+    IsTruncationEnabled: () => boolean;
+    SetAlignment: (drawStringAlignment: DrawStringAlignment) => void;
+    SetLineHeightModifier: (value: float) => void;
+    SetMaxCharacters: (maxChars: int) => void;
+
+    /**
+     * Sets the character that will be used when a missing character in the font needs to be
+     * rendered. This overrides previous `Font:SetMissingCharacter` settings.
+     */
+    SetMissingCharacterOverride: (character: int) => void;
+  }
+}
diff --git a/packages/isaac-typescript-definitions/src/types/classes/Game.d.ts b/packages/isaac-typescript-definitions/src/types/classes/Game.d.ts
index f18c0f786..9b5370ecc 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/Game.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/Game.d.ts
@@ -132,17 +132,26 @@ declare global {
     /**
      * @param speed A value between 0 and 1. Using a value of 0 will soft-lock the game. Using a
      *              value of 1 will instantaneously fade in.
+     * @param showIcon Optional. Defaults to true. This parameter was added in Repentance+.
+     * @param kColor Optional. Defaults to `K_COLORS.Black`. This parameter was added in
+     *               Repentance+.
      */
-    Fadein: (speed: float) => void;
+    Fadein: (speed: float, showIcon?: boolean, kColor?: KColor) => void;
 
     /**
-     * Using non-valid `FadeoutTarget` values will be interpreted the same as `FadeoutTarget.NONE`.
+     * Using a non-valid `FadeoutTarget` value will be interpreted the same as `FadeoutTarget.NONE`.
      *
      * @param speed A value between 0 and 1. Using a value of 0 will never trigger the fade out
      *              target. Using a value of 1 will instantaneously trigger the fade out target.
-     * @param fadeoutTarget
+     * @param fadeoutTarget The place to go after the fade out is completed.
+     * @param kColor Optional. Defaults to `K_COLORS.Black`. This parameter was added in
+     *               Repentance+.
      */
-    Fadeout: (speed: float, fadeoutTarget: FadeoutTarget) => void;
+    Fadeout: (
+      speed: float,
+      fadeoutTarget: FadeoutTarget,
+      kColor?: KColor,
+    ) => void;
 
     /**
      * @param position
diff --git a/packages/isaac-typescript-definitions/src/types/classes/GridEntity.d.ts b/packages/isaac-typescript-definitions/src/types/classes/GridEntity.d.ts
index bde5f2f4a..6653634e7 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/GridEntity.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/GridEntity.d.ts
@@ -4,6 +4,10 @@ import type { GridEntityType } from "../../enums/GridEntityType";
 declare global {
   interface GridEntity extends IsaacAPIClass {
     Destroy: (immediate: boolean) => boolean;
+
+    /** Added in Repentance+. */
+    DestroyWithSource: (immediate: boolean, source: EntityRef) => boolean;
+
     GetGridIndex: () => int;
 
     /** The RNG returned is a reference (i.e. not a copy). */
@@ -17,6 +21,10 @@ declare global {
     GetType: () => GridEntityType;
     GetVariant: () => int;
     Hurt: (damage: int) => boolean;
+
+    /** Added in Repentance+. */
+    HurtWithSource: (damage: int, source: EntityRef) => boolean;
+
     Init: (seed: Seed) => void;
     PostInit: () => void;
     Render: (offset: Vector) => void;
diff --git a/packages/isaac-typescript-definitions/src/types/classes/HUD.d.ts b/packages/isaac-typescript-definitions/src/types/classes/HUD.d.ts
index 87e397022..4feb4d75e 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/HUD.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/HUD.d.ts
@@ -45,9 +45,23 @@ declare global {
     /**
      * Shows the pickup text for the specified item as if it was picked up by the specified player.
      * The overloaded method supports showing custom pickup text.
+     *
+     * The `stackUpText` parameter was added in Repentance+. If it is missing or true, then it
+     * clears the message stack (Repentance functionality). If it is false, then the text will stack
+     * up (Repentance+ functionality). These values are counterintuitive, so it seems likely that
+     * the developers made a mistake.
      */
-    ShowItemText: ((player: EntityPlayer, item: ItemConfigItem) => void)
-      & ((name: string, description?: string, paper?: boolean) => void);
+    ShowItemText: ((
+      player: EntityPlayer,
+      item: ItemConfigItem,
+      stackUpText: boolean,
+    ) => void)
+      & ((
+        mainString: string,
+        secondaryString?: string,
+        isCurseDisplay?: boolean,
+        stackUpText?: boolean,
+      ) => void);
 
     Update: () => void;
   }
diff --git a/packages/isaac-typescript-definitions/src/types/classes/ItemPool.d.ts b/packages/isaac-typescript-definitions/src/types/classes/ItemPool.d.ts
index 00334f931..79f9fdbf1 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/ItemPool.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/ItemPool.d.ts
@@ -26,12 +26,15 @@ declare global {
      * @param decrease Default is false.
      * @param seed Default is `Random()`.
      * @param defaultItem Default is `CollectibleType.NULL`.
+     * @param backupItemPoolType Default is `ItemPoolType.POOL_NULL`. This parameter was added in
+     *                           Repentance+.
      */
     GetCollectible: (
       itemPoolType: ItemPoolType,
       decrease?: boolean,
       seed?: Seed,
       defaultItem?: CollectibleType,
+      backupItemPoolType?: ItemPoolType,
     ) => CollectibleType;
 
     GetLastPool: () => ItemPoolType;
diff --git a/packages/isaac-typescript-definitions/src/types/classes/Options.d.ts b/packages/isaac-typescript-definitions/src/types/classes/Options.d.ts
index 56a7e75c9..fe0d5f7ed 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/Options.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/Options.d.ts
@@ -2,6 +2,7 @@ import type { AnnouncerVoiceMode } from "../../enums/AnnouncerVoiceMode";
 import type { CameraStyle } from "../../enums/CameraStyle";
 import type { ConsoleFont } from "../../enums/ConsoleFont";
 import type { ExtraHudStyle } from "../../enums/ExtraHudStyle";
+import type { JacobEsauControls } from "../../enums/JacobEsauControls";
 import type { LanguageAbbreviation } from "../../enums/LanguageAbbreviation";
 
 declare global {
@@ -120,6 +121,15 @@ declare global {
      */
     let BulletVisibility: boolean;
 
+    /**
+     * Toggles the way to activate Esau's items.
+     *
+     * This can be changed from the in-game options menu.
+     *
+     * Added in Repentance+.
+     */
+    let JacobEsauControls: JacobEsauControls;
+
     /**
      * Whether the announcer voice should play when using items, pills, cards, and runes.
      *
diff --git a/packages/isaac-typescript-definitions/src/types/classes/Room.d.ts b/packages/isaac-typescript-definitions/src/types/classes/Room.d.ts
index 97a5b8854..c5535ba83 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/Room.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/Room.d.ts
@@ -36,7 +36,23 @@ declare global {
     ) => LuaMultiReturn<[clear: boolean, collidePos: Vector]>;
 
     DamageGrid: (index: int, damage: int) => boolean;
+
+    /** Added in Repentance+. */
+    DamageGridWithSource: (
+      index: int,
+      damage: int,
+      source: EntityRef,
+    ) => boolean;
+
     DestroyGrid: (index: int, immediate: boolean) => boolean;
+
+    /** Added in Repentance+. */
+    DestroyGridWithSource: (
+      index: int,
+      immediate: boolean,
+      source: EntityRef,
+    ) => boolean;
+
     EmitBloodFromWalls: (duration: int, count: int) => void;
 
     /**
@@ -204,7 +220,15 @@ declare global {
     IsPositionInRoom: (position: Vector, margin: float) => boolean;
     IsSacrificeDone: () => boolean;
     KeepDoorsClosed: () => void;
-    MamaMegaExplosion: (position: Vector) => void;
+
+    /**
+     * @param position Optional. The position where the explosion should originate. Default is
+     *                 `Vector.Zero`.
+     * @param player Optional. The player that the explosion should come from. This parameter was
+     *               added in Repentance+.
+     */
+    MamaMegaExplosion: (position?: Vector, player?: EntityPlayer) => void;
+
     PlayMusic: () => void;
     RemoveDoor: (doorSlot: DoorSlot) => void;
 
diff --git a/packages/isaac-typescript-definitions/src/types/classes/Sprite.d.ts b/packages/isaac-typescript-definitions/src/types/classes/Sprite.d.ts
index 538f9d3d8..e2cb41009 100644
--- a/packages/isaac-typescript-definitions/src/types/classes/Sprite.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/classes/Sprite.d.ts
@@ -187,8 +187,11 @@ declare interface Sprite extends IsaacAPIClass {
    * @param layerID
    * @param pngPath The full path to the PNG file. For example:
    * "gfx/items/collectibles/questionmark.png"
+   * @returns `true` if the spritesheet at the given layer ID was successfully replaced and if the
+   *          new spritesheet is not the same as the old one, otherwise `false`. This return value
+   *          was added in Repentance+.
    */
-  ReplaceSpritesheet: (layerID: int, pngPath: string) => void;
+  ReplaceSpritesheet: (layerID: int, pngPath: string) => boolean;
 
   /**
    * Resets the sprite such that it will be equivalent to a new sprite created with the `Sprite`
diff --git a/packages/isaac-typescript-definitions/src/types/index.d.ts b/packages/isaac-typescript-definitions/src/types/index.d.ts
index 6107fbd02..9abf7cb90 100644
--- a/packages/isaac-typescript-definitions/src/types/index.d.ts
+++ b/packages/isaac-typescript-definitions/src/types/index.d.ts
@@ -45,6 +45,7 @@
 /// <reference path="./classes/EntityTear.d.ts" />
 /// <reference path="./classes/EntriesList.d.ts" />
 /// <reference path="./classes/Font.d.ts" />
+/// <reference path="./classes/FontRenderSettings.d.ts" />
 /// <reference path="./classes/Game.d.ts" />
 /// <reference path="./classes/GridEntity.d.ts" />
 /// <reference path="./classes/GridEntityDesc.d.ts" />
diff --git a/packages/isaacscript-spell/dictionaries/isaac/api.txt b/packages/isaacscript-spell/dictionaries/isaac/api.txt
index 8e4c3c0be..2319fb0df 100644
--- a/packages/isaacscript-spell/dictionaries/isaac/api.txt
+++ b/packages/isaacscript-spell/dictionaries/isaac/api.txt
@@ -49,6 +49,7 @@ cutscenes
 CYCLOPIA
 DAGAZ
 DATAMINER
+DEATHMATCH
 DECAP
 DERP
 DINGA